Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.63 |
| ▸ | MME | P08473 | 3/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445121 | 1.00 | ACE (0.63) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7451325 | 0.91 | ACE (0.60) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7451333 | 0.91 | ACE (0.60) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7349691 | 0.88 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7349703 | 0.88 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7349696 | 0.88 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7449059 | 0.88 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7443008 | 0.86 | ACE (0.69) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7443017 | 0.86 | ACE (0.69) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7437258 | 0.85 | ACE (0.62) | ACEMMEHRH4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026719-A1 | MERCAPTO-AMIDE DERIVATIVES USEFUL AS NEUTRAL ENDOPEPTIDASE AND ACE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-24 | — | — | WO | disclosed |