SCHEMBL7349932

SCHEMBL7349932

COc1cccc(N(C(=O)CN2CCN(C)CC2)c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.52
ALDH1A1 P00352 3/20 0.52
TP53 P04637 1/20 0.52
CACNA2D1 P54289 4/20 0.51
CACNA1B Q00975 4/20 0.51
CACNB1 Q02641 4/20 0.51
CACNA1C Q13936 4/20 0.51
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 2/20 0.48
HTT P42858 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
GAA P10253 2/20 0.47
OPRM1 P35372 1/20 0.47
MTNR1A P48039 1/20 0.46
MTNR1B P49286 1/20 0.46
PTGIR P43119 1/20 0.46
PTGDR Q13258 1/20 0.46
GFER P55789 2/20 0.46
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7342363 0.86 ALDH1A1 (0.48) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7339023 0.86 CACNA2D1 (0.65) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7340551 0.84 CACNA2D1 (0.56) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7342508 0.84 CACNA2D1 (0.54) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7346581 0.83 MAPT (0.49) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7370201 0.83 CACNA2D1 (0.65) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7343423 0.83 ESR1 (0.46) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7343448 0.82 ALDH1A1 (0.47) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7341570 0.82 CACNA2D1 (0.52) LMNAALDH1A1TP53CACNA2D1CACNA1B
SCHEMBL7342768 0.82 TLR7 (0.49) LMNAALDH1A1TP53CACNA2D1CACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0658157-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL PHARMACEUTICALS INC. (US) 1995-06-21 EP claimed
WO-1994005648-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-17 WO claimed
EP-0658157-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL PHARMACEUTICALS INC. (US) 1995-06-21 EP disclosed
WO-1994005648-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-17 WO disclosed
EP-0585500-A1 Diaryl piperazineacetamides as antimuscarinic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-09 EP disclosed