Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 5/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8731751 | 0.91 | NPC1 (0.55) | NPC1RAB9ABCHESMN1; SMN2HTR1A | |
| SCHEMBL7140583 | 0.85 | HPGD (0.54) | NPC1RAB9ASCN9ASMN1; SMN2HTR1A | |
| SCHEMBL2821669 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2SRC | |
| SCHEMBL9428004 | 0.83 | ALDH1A1 (0.65) | SMN1; SMN2SRC | |
| SCHEMBL6000358 | 0.83 | ALDH1A1 (0.65) | SMN1; SMN2SRC | |
| SCHEMBL10958852 | 0.83 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2PTGER4PTGER3 | |
| SCHEMBL7355906 | 0.82 | PRMT1 (0.62) | NPC1RAB9ABCHESCN9ASMN1; SMN2 | |
| SCHEMBL7355908 | 0.82 | PRMT1 (0.62) | NPC1RAB9ABCHESCN9ASMN1; SMN2 | |
| SCHEMBL636327 | 0.82 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2SRC | |
| SCHEMBL1125006 | 0.82 | KDM4E (0.60) | NPC1RAB9ABCHEPTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |