Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835865 | 1.00 | PDE5A (0.58) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5595379 | 0.87 | PDE5A (0.66) | PDE5A | |
| SCHEMBL7346033 | 0.87 | PDE5A (0.66) | PDE5A | |
| SCHEMBL5595341 | 0.84 | PDE5A (0.61) | PDE5A | |
| SCHEMBL7347444 | 0.84 | PDE5A (0.61) | PDE5A | |
| SCHEMBL3841327 | 0.83 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3836975 | 0.80 | PDE5A (0.76) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7795495 | 0.77 | NPC1 (0.48) | PDE5A | |
| SCHEMBL3842772 | 0.77 | PDE5A (0.75) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7348770 | 0.75 | PDE5A (1.00) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993300-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0993300-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| WO-1998048798-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |
| WO-1993007149-A1 | PYRAZOLOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-04-15 | — | — | WO | disclosed |