Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 15/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351669 | 0.86 | AVPR2 (0.51) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7345372 | 0.86 | AVPR2 (0.55) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7350004 | 0.84 | AVPR2 (0.54) | AVPR2ALDH1A1 | |
| SCHEMBL7349853 | 0.84 | AVPR2 (0.50) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7350223 | 0.83 | PDK1 (0.49) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7353114 | 0.83 | AVPR2 (0.55) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7346624 | 0.83 | AVPR2 (0.60) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7351937 | 0.82 | AVPR2 (0.52) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7351466 | 0.80 | AVPR2 (0.50) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7349670 | 0.79 | AVPR2 (0.56) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |