Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CDC25B | P30305 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349511 | 0.88 | CDC25B (0.61) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13243719 | 0.88 | KMT2A (0.56) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7352496 | 0.87 | MAPT (0.61) | MAPTKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL1357559 | 0.87 | CDC25B (0.65) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13243723 | 0.87 | AKR1C3 (0.74) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11147733 | 0.86 | MAPT (0.68) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13243718 | 0.86 | AKR1C4 (0.73) | MAPTKMT2ALMNAMAPK1CDC25B | |
| SCHEMBL13243717 | 0.85 | KMT2A (0.53) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1356910 | 0.85 | KMT2A (0.53) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15320701 | 0.84 | HCAR3 (0.68) | MAPTKMT2ASMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |