Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.58 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.45 |
| ▸ | FEN1 | P39748 | 2/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955880 | 0.80 | GRIA1 (0.71) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9395757 | 0.78 | SMN1; SMN2 (0.56) | GRIA1GRIA2GRIA3GRIA4ERCC1 | |
| SCHEMBL7350271 | 0.77 | GRIA1 (0.63) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7356050 | 0.77 | GRIA1 (0.63) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7356582 | 0.77 | GRIN2D (0.63) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7349363 | 0.77 | GRIA1 (0.63) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7355341 | 0.77 | GRIN2D (0.63) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL8609111 | 0.75 | PSMB8 (0.53) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL6745420 | 0.75 | ERCC1 (0.54) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL7357397 | 0.74 | GRIA2 (0.59) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | disclosed |