Guanidine

Guanidine

SCHEMBL735063

N=C(N)N.O=S([O-])O.[H+]

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2

The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanidine SCHEMBL2057451 0.81 CA1 (0.55)
Guanidine SCHEMBL735066 0.81
Sulfurous Acid SCHEMBL8846189 0.80 CA1 (0.50)
Sulfurous Acid SCHEMBL28203988 0.80
Guanidine SCHEMBL27667765 0.79 MEN1 (0.32)
Guanidine SCHEMBL11335102 0.77
Guanidine SCHEMBL3140647 0.77 CA1 (0.39)
Guanidine SCHEMBL11341418 0.77
Sulfurous Acid SCHEMBL9434272 0.76
Sulfurous Acid SCHEMBL632313 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100092972-A1 ASSAY FOR GENE EXPRESSION HUMAN GENETIC SIGNATURES PTY LTD. (AU) 2010-04-15 US claimed
US-7501240-B2 Method for bisulfite treatment ROCHE MOLECULAR SYSTEMS, INC. (US) 2009-03-10 US claimed
US-20070190530-A1 Method for bisulfite treatment ROCHE MOLECULAR SYSTEMS, INC. 2007-08-16 US claimed
EP-1692315-A1 IMPROVED METHOD FOR BISULFITE TREATMENT Roche Diagnostics GmbH (DE) 2006-08-23 EP claimed
WO-2005054502-A1 IMPROVED METHOD FOR BISULFITE TREATMENT ROCHE DIAGNOSTICS GMBH (DE) 2005-06-16 WO claimed
EP-2016188-B1 METHODS FOR DETECTION OF METHYLATED DNA JIA XIYU (US) 2015-10-21 EP disclosed
EP-2330214-B1 Method for DNA decontamination HOFFMANN LA ROCHE (CH) 2015-03-04 EP disclosed
EP-1789586-B1 DNA DECONTAMINATION METHOD ROCHE DIAGNOSTICS GMBH (DE) 2014-12-31 EP disclosed
US-8137937-B2 Conversion of cytosine base in nucleic acid to uracil base via sulfite deamination; determining methylation positions in nucleotide sequences ROCHE MOLECULAR SYSTEMS, INC. (US) 2012-03-20 US disclosed
US-7989169-B2 Selective amplification of methylated nucleic acids ROCHE MOLECULAR SYSTEMS, INC. (US) 2011-08-02 US disclosed
EP-2330214-A1 Method for DNA decontamination F. Hoffmann-La Roche AG (CH) 2011-06-08 EP disclosed
EP-1963352-B1 NEW METHOD FOR BISULFITE TREATMENT ROCHE DIAGNOSTICS GMBH (DE) 2010-09-08 EP disclosed
US-20070190530-A1 Method for bisulfite treatment ROCHE MOLECULAR SYSTEMS, INC. 2007-08-16 US disclosed
WO-2007068437-A1 NEW METHOD FOR BISULFITE TREATMENT ROCHE DIAGNOSTICS GMBH (DE) 2007-06-21 WO disclosed
EP-1789586-A2 DNA DECONTAMINATION METHOD Roche Diagnostics GmbH (DE) 2007-05-30 EP disclosed
EP-1692315-A1 IMPROVED METHOD FOR BISULFITE TREATMENT Roche Diagnostics GmbH (DE) 2006-08-23 EP disclosed
EP-1692315-A1 IMPROVED METHOD FOR BISULFITE TREATMENT Roche Diagnostics GmbH (DE) 2006-08-23 EP disclosed
WO-2006024541-A2 DNA DECONTAMINATION METHOD ROCHE DIAGNOSTICS GMBH (DE) 2006-03-09 WO disclosed
WO-2005054502-A1 IMPROVED METHOD FOR BISULFITE TREATMENT ROCHE DIAGNOSTICS GMBH (DE) 2005-06-16 WO disclosed
WO-2005054502-A1 IMPROVED METHOD FOR BISULFITE TREATMENT ROCHE DIAGNOSTICS GMBH (DE) 2005-06-16 WO disclosed