Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL2057451 | 1.00 | CA1 (0.55) | — | |
| Guanidine SCHEMBL11341418 | 0.96 | — | — | |
| Guanidine SCHEMBL11335102 | 0.96 | — | — | |
| Guanidine SCHEMBL3140647 | 0.87 | CA1 (0.39) | — | |
| Thiourea SCHEMBL11227944 | 0.81 | — | — | |
| Guanidine SCHEMBL735063 | 0.81 | — | — | |
| SCHEMBL42684 | 0.78 | — | — | |
| Urea SCHEMBL8087814 | 0.76 | — | — | |
| Sulfurous Acid SCHEMBL25206600 | 0.75 | — | — | |
| Guanidine SCHEMBL27640020 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103628306-B | A kind of preparation method of shitosan list guanidine hydrochloride load nano-titanium dioxide compound | PULCRA SPECIALTY CHEMICALS (SHANGHAI) CO., LTD. (CN) | 2016-03-02 | — | — | CN | claimed |
| CN-103628306-A | Chitosan single guanidine hydrochloride loaded nanometer titanium dioxide compound and preparation method thereof | KEKAI FINE CHEMICAL SHANGHAI CO LTD | 2014-03-12 | — | — | CN | claimed |
| US-20110003292-A1 | METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELL PROLIFERATIVE DISORDERS | EPIGENOMICS AG (DE) | 2011-01-06 | — | — | US | claimed |
| EP-2229456-A2 | METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELL PROLIFERATIVE DISORDERS | Epigenomics AG (DE) | 2010-09-22 | — | — | EP | claimed |
| US-20100092972-A1 | ASSAY FOR GENE EXPRESSION | HUMAN GENETIC SIGNATURES PTY LTD. (AU) | 2010-04-15 | — | — | US | claimed |
| WO-2009074328-A2 | METHODS AND NUCLEIC ACIDS FOR ANALYSES OF LUNG CARCINOMA | EPIGENOMICS AG (DE) | 2009-06-18 | — | — | WO | claimed |
| US-7501240-B2 | Method for bisulfite treatment | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2009-03-10 | — | — | US | claimed |
| CN-100371375-C | Polycarbonate resin compositions and articles therefrom | GEN ELECTRIC (US) | 2008-02-27 | — | — | CN | claimed |
| US-20070190530-A1 | Method for bisulfite treatment | ROCHE MOLECULAR SYSTEMS, INC. | 2007-08-16 | — | — | US | claimed |
| US-7256230-B2 | Flame retardant polycarbonate resin and articles with guanidine salts having high transparency | GENERAL ELECTRIC COMPANY (US) | 2007-08-14 | — | — | US | claimed |
| EP-1423468-B1 | POLYCARBONATE RESIN COMPOSITIONS AND ARTICLES THEREFROM | GEN ELECTRIC (US) | 2005-12-21 | — | — | EP | claimed |
| WO-2005054502-A1 | IMPROVED METHOD FOR BISULFITE TREATMENT | ROCHE DIAGNOSTICS GMBH (DE) | 2005-06-16 | — | — | WO | claimed |
| CN-1564844-A | Polycarbonate resin compositions and articles therefrom | GEN ELECTRIC (US) | 2005-01-12 | — | — | CN | claimed |
| EP-1423468-A1 | POLYCARBONATE RESIN COMPOSITIONS AND ARTICLES THEREFRO | GENERAL ELECTRIC COMPANY (US) | 2004-06-02 | — | — | EP | claimed |
| US-6716902-B2 | AN AROMATIC POLYCARBONATE RESIN AND A FLAME RETARDING AMOUNT OF A GUANIDINE SALT INCREASES ITS PASS RATE IN A SPECIFIC DRIPPING TEST, WHILE STILL RETAINING ITS RADIATION TRANSPARENT QUALITY AND OTHER PROPERTIES | GENERAL ELECTRIC COMPANY | 2004-04-06 | — | — | US | claimed |
| US-20030100642-A1 | Polycarbonate resin compositions and articles therefrom | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2003-05-29 | — | — | US | claimed |
| WO-2003027176-A1 | POLYCARBONATE RESIN COMPOSITIONS AND ARTICLES THEREFRO | GENERAL ELECTRIC COMPANY (US) | 2003-04-03 | — | — | WO | claimed |
| US-6518340-B1 | Flame retardant polycarbonate resin compositions and articles with guanidine salts having high transparency | GENERAL ELECTRIC COMPANY | 2003-02-11 | — | — | US | claimed |
| US-4303085-A | STRAIGHTENING WITH GUANIDINE SALT | CARSON PRODUCTS COMPANY (US) | 1981-12-01 | — | — | US | claimed |
| US-4246285-A | Skin conditioning compositions containing guanidine inorganic salts | THE PROCTER & GAMBLE COMPANY (US) | 1981-01-20 | — | — | US | claimed |