SCHEMBL7350744

SCHEMBL7350744

N[C@@H](Cc1ccccc1)C[C@H](O)CC(NC(=O)OCc1cncs1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 19/20 0.51
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL893383 0.84 CYP3A4 (0.55) CYP3A4TDP1
SCHEMBL893198 0.84 CYP3A4 (0.55) CYP3A4TDP1
SCHEMBL2919212 0.84 TDP1 (0.50) CYP3A4TDP1
Hydrochloric Acid SCHEMBL7389969 0.83 CYP3A4 (0.55) CYP3A4TDP1
Hydrochloric Acid SCHEMBL31236647 0.83 CYP3A4 (0.55) CYP3A4TDP1
SCHEMBL7196078 0.83 CYP3A4 (0.54) CYP3A4TDP1
SCHEMBL7181197 0.83 CYP3A4 (0.54) CYP3A4TDP1
SCHEMBL9064880 0.80 CYP3A4 (0.61) CYP3A4
SCHEMBL4677833 0.80 CYP3A4 (0.61) CYP3A4
SCHEMBL9065625 0.80 CYP3A4 (0.61) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5541334-A TREATING HIV ABBOTT LABORATORIES (US) 1996-07-30 US disclosed
US-5541206-A TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTION ABBOTT LABORATORIES (US) 1996-07-30 US disclosed