Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343776 | 0.89 | ALDH1A1 (0.52) | SIGMAR1ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7340543 | 0.88 | ALDH1A1 (0.55) | SIGMAR1ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7349999 | 0.85 | MEN1 (0.56) | ALDH1A1HSD17B10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21103823 | 0.82 | HSD17B10 (0.50) | IDO1CSNK1A1TMEM97SIGMAR1HTR1A | |
| SCHEMBL27306803 | 0.81 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1SMN1; SMN2CYP3A4 | |
| SCHEMBL305765 | 0.80 | ALDH1A1 (0.51) | IDO1CSNK1A1TMEM97SIGMAR1HTR1A | |
| SCHEMBL23130581 | 0.79 | MAPT (0.46) | IDO1TMEM97SIGMAR1HTR1AADRA2A | |
| SCHEMBL20399260 | 0.79 | MAPT (0.46) | IDO1TMEM97SIGMAR1HTR1AADRA2A | |
| SCHEMBL20666387 | 0.77 | ALDH1A1 (0.45) | IDO1CSNK1A1TMEM97SIGMAR1HTR1A | |
| SCHEMBL9224504 | 0.76 | ALDH1A1 (0.46) | SIGMAR1ALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0480939-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1992-04-22 | — | — | EP | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |