Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | THPO | P40225 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.66 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10918103 | 1.00 | MAPT (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7341750 | 0.96 | CACNA1F (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7279871 | 0.95 | MAPT (0.66) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10742637 | 0.95 | MAPT (0.69) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9675181 | 0.95 | MEN1 (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9672729 | 0.94 | CACNA1F (0.68) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7274108 | 0.94 | CACNA1F (0.75) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7282141 | 0.93 | CACNA1F (0.69) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9674767 | 0.93 | CACNA1F (0.69) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7346945 | 0.93 | CACNA1F (0.69) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | claimed |
| US-5258519-A | FOR TREATMENT OF HYPERTENSION AND CARDIAC CONDITIONS | GLAXO INC. (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0250725-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1992-11-04 | — | — | EP | disclosed |
| US-5100892-A | Hypotensive agents, congestive heart failure | GLAXO INC. (US) | 1992-03-31 | — | — | US | disclosed |
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4757080-A | Pharmaceuticals | HEUMANN PHARMA GMBH & CO. (DE) | 1988-07-12 | — | — | US | disclosed |
| EP-0250725-A1 | 1,4-Dihydropyridine derivatives, processes for their preparation and medicaments containing them | HEUMANN PHARMA GMBH & CO (DE) | 1988-01-07 | — | — | EP | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |