SCHEMBL7351371

SCHEMBL7351371

COC(=O)C1=C(C)NC(C)=C(C(=O)OCCC2NCc3ccccc32)C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.66
ADORA3 P0DMS8 6/20 0.66
LMNA P02545 6/20 0.66
MAPT P10636 6/20 0.66
CYP3A4 P08684 6/20 0.66
CYP2C9 P11712 6/20 0.66
CYP2C19 P33261 6/20 0.66
KMT2A Q03164 5/20 0.66
CYP2D6 P10635 5/20 0.66
CACNA1C Q13936 4/20 0.66
HIF1A Q16665 4/20 0.66
ABCC4 O15439 3/20 0.66
ABCB11 O95342 3/20 0.66
OPRM1 P35372 3/20 0.66
KCNH2 Q12809 3/20 0.66
SCN5A Q14524 3/20 0.66
TSHR P16473 3/20 0.66
CACNA1F O60840 2/20 0.66
ADORA2A P29274 2/20 0.66
ADORA1 P30542 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7346366 0.93 CYP1A2 (0.56) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7343704 0.91 CYP1A2 (0.54) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7343967 0.89 CYP1A2 (0.52) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7349496 0.86 CYP1A2 (0.48) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7343611 0.85 CYP1A2 (0.66) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7347859 0.85 MAPT (0.48) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7349531 0.85 ADORA3 (0.55) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7348034 0.85 CACNA1C (0.46) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL7343553 0.85 ADORA3 (0.45) CYP1A2ADORA3LMNAMAPTCYP3A4
SCHEMBL11824944 0.84 CYP1A2 (0.82) CYP1A2ADORA3LMNAMAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4833150-A HYPOTENSIVES, ANTIARRHYTHMIA AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1989-05-23 US disclosed
US-4652573-A HYPOTENSIVE AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1987-03-24 US disclosed
EP-0194685-A1 1,4-Dihydropyridines Whitby Research Incorporated (US) 1986-09-17 EP disclosed