Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349349 | 0.83 | KDM4E (0.66) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL22284877 | 0.81 | KDM4E (0.62) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL7348325 | 0.78 | KDM4E (0.56) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL7982729 | 0.78 | KDM4E (0.56) | KDM4ESTAT3HIF1AALDH1A1HSD17B10 | |
| SCHEMBL29805260 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL498053 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL928139 | 0.76 | KDM4E (0.72) | KDM4ESTAT3HIF1AALDH1A1TP53 | |
| SCHEMBL6530251 | 0.75 | NPC1 (0.68) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL25380488 | 0.74 | KDM4E (0.71) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL11485891 | 0.74 | KDM4E (0.71) | KDM4ESTAT3HIF1AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214834-B1 | ANGIOGENESIS INHIBITORS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | disclosed |
| WO-1998043962-A1 | HETEROCYCLIC INTEGRIN INHIBITOR PRODRUGS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | disclosed |
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |