Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.62 |
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349349 | 0.83 | KDM4E (0.66) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL7351471 | 0.81 | KDM4E (0.62) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL4605405 | 0.78 | KDM4E (0.67) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL29805260 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL498053 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL928139 | 0.76 | KDM4E (0.72) | KDM4ESTAT3HIF1AALDH1A1NPC1 | |
| SCHEMBL7982729 | 0.76 | KDM4E (0.56) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL7348325 | 0.76 | KDM4E (0.56) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL25380488 | 0.74 | KDM4E (0.71) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 | |
| SCHEMBL11485891 | 0.74 | KDM4E (0.71) | KDM4ESTAT3HIF1AALDH1A1YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548860-B2 | Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1 | MANGOSUTHU UNIVERSITY OF TECHNOLOGY (ZA) | 2023-01-10 | — | — | US | disclosed |
| US-20200247764-A1 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | MANGOSUTHU UNIVERSITY TECHNOLOGY (ZA) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247764-A1 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | CYP19A1, CYP26A1, CYP21A2 | KDM4E 2047/4885STAT3 1813/4885HIF1A 986/4885 |
| US-11548860-B2 | Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1 | CYP19A1, CYP26A1, CYP21A2 | KDM4E 2047/4885STAT3 1813/4885HIF1A 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.