Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.74 |
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP7 | P09237 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP12 | P39900 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.58 |
| ▸ | CPA1 | P15085 | 1/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097324 | 1.00 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL5654462 | 1.00 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL5654469 | 1.00 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL10878801 | 0.92 | MME (0.67) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL10877122 | 0.89 | BIRC2 (0.67) | MME | |
| SCHEMBL10877116 | 0.89 | BIRC2 (0.67) | MME | |
| SCHEMBL15223611 | 0.88 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL10878767 | 0.87 | MME (0.62) | MMELTA4H | |
| SCHEMBL9068697 | 0.87 | MME (0.72) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL5869124 | 0.85 | MME (1.00) | MMELTA4HACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-4749688-A | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |