Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.72 |
| ▸ | LTA4H | P09960 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 3/20 | 0.56 |
| ▸ | CPA1 | P15085 | 1/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256139 | 0.89 | MME (0.58) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL9555877 | 0.87 | BIRC2 (0.67) | MME | |
| SCHEMBL9555884 | 0.87 | BIRC2 (0.67) | MME | |
| SCHEMBL5097324 | 0.87 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL15223611 | 0.87 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL7352159 | 0.87 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL5654469 | 0.87 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL5654462 | 0.87 | MME (0.74) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL11119114 | 0.86 | MME (0.69) | MMEACECPA1ACE2 | |
| SCHEMBL11119113 | 0.86 | MME (0.69) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |