Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959243 | 0.91 | CA2 (0.59) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL8959195 | 0.86 | CA2 (0.61) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL9999756 | 0.85 | CA1 (0.52) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL1086609 | 0.85 | CA1 (0.52) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL6693439 | 0.85 | CA1 (0.52) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL8959175 | 0.84 | CA2 (0.63) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL10990333 | 0.81 | CA2 (0.55) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL9417678 | 0.80 | CA2 (0.46) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL9417725 | 0.80 | CA2 (0.46) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL11586010 | 0.79 | CA2 (0.57) | CA2CA1MAPTHPNALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675883-A1 | PIPERIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994014786-A1 | PIPERIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |