Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11204407 | 0.80 | PABPC1 (0.59) | GLAKMT2APABPC1ATMHTT | |
| Bromide SCHEMBL11489914 | 0.80 | GLA (0.53) | GLAKMT2APABPC1ATMHTT | |
| Hydrochloric Acid SCHEMBL11424376 | 0.77 | ATM (0.55) | GLAKMT2APABPC1ATMHTT | |
| Hydrochloric Acid SCHEMBL11490843 | 0.77 | GLA (0.50) | GLAKMT2APABPC1ATMHTT | |
| Bromide SCHEMBL1193574 | 0.76 | GLA (0.70) | GLAKMT2APABPC1ATMHTT | |
| Bromide SCHEMBL344154 | 0.76 | KMT2A (0.50) | GLAKMT2AHTTALDH1A1KDM4E | |
| SCHEMBL22776049 | 0.76 | KMT2A (0.49) | GLAKMT2APABPC1ATMHTT | |
| SCHEMBL6904837 | 0.75 | GLA (0.68) | GLAKMT2APABPC1ATMHTT | |
| SCHEMBL14621510 | 0.74 | GLA (0.57) | GLAKMT2APABPC1ATMHTT | |
| Bromide SCHEMBL7695782 | 0.74 | GLA (0.48) | GLAKMT2APABPC1ATMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001854-A | CYCLIC AMINES FOR INHIBITING GLYCINE TRANSPORT VIA GLYCINET-1 OR GLYCINET-2 TRANSPORTER; USEFUL FOR TREATING PSYCHOLOGICAL AND OTHER BRAIN DISORDERS | ALLELIX NEUROSCIENCE INC. (US) | 1999-12-14 | — | — | US | disclosed |