Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347052 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1POLBL3MBTL1AVPR2 | |
| SCHEMBL7345463 | 0.87 | AVPR1A (0.46) | AVPR2AVPR1AOXTR | |
| SCHEMBL7351374 | 0.83 | CNR2 (0.46) | SMN1; SMN2ALDH1A1POLBKMT2AAVPR2 | |
| SCHEMBL7345074 | 0.81 | HTT (0.41) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL7345048 | 0.81 | HTT (0.42) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL7346907 | 0.81 | HTT (0.42) | SMN1; SMN2ALDH1A1POLBAVPR2AVPR1A | |
| SCHEMBL7346705 | 0.81 | HTT (0.43) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL7352960 | 0.80 | HTT (0.41) | SMN1; SMN2ALDH1A1POLBAVPR2AVPR1A | |
| SCHEMBL7344248 | 0.80 | AVPR2 (0.68) | AVPR2AVPR1AOXTR | |
| SCHEMBL7353042 | 0.79 | AVPR1A (0.43) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5587377-A | HYPOTENSIVE AGENT | INVAMED, INC. (US) | 1996-12-24 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |