Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350260 | 0.72 | HRH1 (0.55) | HRH1HRH4HRH3HRH2CHRM2 | |
| SCHEMBL13200326 | 0.69 | DYRK1A (0.50) | HRH1HRH4HRH3HRH2DRD4 | |
| SCHEMBL605605 | 0.68 | HRH4 (0.53) | HRH1HRH4HRH3HRH2CHRM2 | |
| SCHEMBL7356862 | 0.66 | BCHE (0.46) | DRD4SMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL602974 | 0.65 | HRH4 (0.54) | HRH1HRH4HRH3HRH2CHRM2 | |
| SCHEMBL602988 | 0.65 | HRH4 (0.54) | HRH1HRH4HRH3HRH2CHRM2 | |
| SCHEMBL7278648 | 0.64 | ACHE (0.45) | HRH4HRH3CHRM2CHRM1CHRM4 | |
| SCHEMBL7281520 | 0.64 | HRH3 (0.43) | HRH3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7947523 | 0.63 | MAPT (0.54) | SMN1; SMN2ALDH1A1LMNAHPGDHTT | |
| SCHEMBL3436987 | 0.63 | SMN1; SMN2 (0.71) | HRH1HRH3CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880121-A | SEROTONIN 5HT3 ANTAGONIST, USEFUL FOR TREATING ANXIETY, PHYCHIATRIC DISORDERS, NAUSEA, VOMITING AND DRUG DEPENDENCY | HOECHST MARION ROUSSEL INC. (US) | 1999-03-09 | — | — | US | disclosed |