SCHEMBL7353249

SCHEMBL7353249

CCCCCCNCc1ccc(N(C)C)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.66
HRH3 Q9Y5N1 1/20 0.66
LMNA P02545 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.62
CYP1A2 P05177 2/20 0.60
CYP2D6 P10635 2/20 0.60
CYP2C19 P33261 2/20 0.60
CHRM2 P08172 4/20 0.53
S1PR1 P21453 5/20 0.51
S1PR3 Q99500 5/20 0.51
S1PR2 O95136 4/20 0.51
S1PR4 O95977 2/20 0.51
HDAC11 Q96DB2 2/20 0.50
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC8 Q9BY41 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11528225 1.00 HRH4 (0.66) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL11525991 1.00 HRH4 (0.66) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL11922710 0.98 HRH4 (0.68) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL5791746 0.93 HRH4 (0.59) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL17832854 0.91 CHRM2 (0.57) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL2936645 0.87 CA12 (0.55) HRH4HRH3SMN1; SMN2CHRM2HDAC11
SCHEMBL9637156 0.87 HRH4 (0.84) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL10748421 0.87 HRH4 (0.84) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL9259496 0.87 HRH4 (0.84) HRH4HRH3LMNASMN1; SMN2CYP1A2
SCHEMBL10747074 0.87 HRH4 (0.84) HRH4HRH3LMNASMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140792-A1 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE DERIVATIVES WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-10 EP disclosed
US-6166050-A 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4 AMERICAN HOME PRODUCTS CORPORATION (US) 2000-12-26 US disclosed
WO-2000035855-A1 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE DERIVATIVES WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-22 WO disclosed
US-4157343-A Preparation of aromatic diamines UOP INC. (US) 1979-06-05 US disclosed
US-4157343-A Preparation of aromatic diamines UOP INC. (US) 1979-06-05 US disclosed