Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.57 |
| ▸ | METAP1 | P53582 | 7/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353062 | 1.00 | METAP2 (0.57) | METAP2METAP1EPHX1HPGDKMT2A | |
| SCHEMBL7356710 | 1.00 | METAP2 (0.57) | METAP2METAP1EPHX1HPGDKMT2A | |
| SCHEMBL7351278 | 1.00 | METAP2 (0.57) | METAP2METAP1EPHX1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7356093 | 0.98 | METAP2 (0.56) | METAP2METAP1EPHX1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7359793 | 0.98 | METAP2 (0.56) | METAP2METAP1EPHX1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7352831 | 0.98 | METAP2 (0.56) | METAP2METAP1EPHX1HPGDKMT2A | |
| SCHEMBL7351340 | 0.98 | METAP2 (0.56) | METAP2METAP1EPHX1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7361763 | 0.97 | METAP2 (0.54) | METAP2METAP1EPHX1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL14973792 | 0.95 | METAP2 (0.56) | METAP2METAP1EPHX1HPGDKMT2A | |
| SCHEMBL842176 | 0.92 | METAP2 (0.52) | METAP2METAP1EPHX1KMT2ACPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |