Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 14/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354496 | 0.91 | CACNA1B (0.54) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7358808 | 0.91 | CACNA1B (0.58) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7967526 | 0.89 | CACNA1B (0.65) | CACNA1B | |
| SCHEMBL7355987 | 0.87 | CACNA1B (0.55) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7349612 | 0.87 | CACNA1B (0.67) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7045341 | 0.81 | CACNA1B (0.59) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7037966 | 0.81 | CACNA1B (0.59) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7037965 | 0.81 | CACNA1B (0.59) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7391996 | 0.80 | CACNA1B (0.59) | CACNA1BLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7354530 | 0.79 | CACNA1B (0.46) | CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999007689-A1 | ANILINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |