Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 2/20 | 0.41 |
| ▸ | IRAK1 known ✓ | P51617 | 2/20 | 0.41 |
| ▸ | JAK3 known ✓ | P52333 | 1/20 | 0.41 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.39 |
| ▸ | ACVR1 known ✓ | Q04771 | 1/20 | 0.38 |
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.41 |
| ▸ | PIM1 | P11309 | 4/20 | 0.41 |
| ▸ | PRKACA | P17612 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL735515 | 1.00 | DYRK1A (0.41) | DYRK1APIM1PRKACAGSK3BCHEK1 | |
| SCHEMBL733287 | 0.87 | TMEM97 (0.45) | DYRK1APIM1PRKACAGSK3BCHEK1 | |
| SCHEMBL3930943 | 0.81 | DYRK1A (0.42) | DYRK1APIM1PRKACAGSK3BCHEK1 | |
| SCHEMBL733637 | 0.72 | SLC6A4 (0.51) | OPRM1OPRL1DRD2LMNAHTR2A | |
| SCHEMBL734778 | 0.71 | TMEM97 (0.50) | DYRK1APIM1PRKACAGSK3BCHEK1 | |
| Citric Acid SCHEMBL735739 | 0.70 | MAPT (0.39) | OPRM1OPRL1DRD2LMNA | |
| Citric Acid SCHEMBL3165180 | 0.69 | HTR2A (0.45) | OPRM1OPRL1DRD2LMNAHTR2A | |
| SCHEMBL734100 | 0.69 | OPRM1 (0.40) | OPRM1OPRL1 | |
| Citric Acid SCHEMBL2781326 | 0.68 | MAPT (0.47) | DYRK1APIM1PRKACAGSK3BCHEK1 | |
| SCHEMBL734179 | 0.68 | OPRM1 (0.37) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | FLT3 319/4885IRAK1 4761/4885JAK3 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.