Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333936 | 0.83 | AVPR2 (0.81) | AVPR2AVPR1A | |
| SCHEMBL8944504 | 0.79 | AVPR2 (0.52) | AVPR2AVPR1AALDH1A1RAB9ANPC1 | |
| SCHEMBL7339753 | 0.78 | AVPR2 (0.57) | AVPR2AVPR1A | |
| SCHEMBL8312651 | 0.78 | AVPR2 (0.72) | AVPR2AVPR1A | |
| SCHEMBL7349745 | 0.77 | AVPR2 (0.55) | AVPR2AVPR1A | |
| SCHEMBL7349870 | 0.77 | AVPR2 (0.61) | AVPR2AVPR1A | |
| SCHEMBL7337720 | 0.77 | AVPR2 (0.70) | AVPR2AVPR1A | |
| SCHEMBL8313226 | 0.77 | AVPR2 (0.70) | AVPR2AVPR1A | |
| SCHEMBL7346245 | 0.76 | AVPR2 (0.58) | AVPR2AVPR1ASMN1; SMN2 | |
| SCHEMBL8314271 | 0.75 | AVPR2 (0.81) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |