Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.47 |
| ▸ | PDE4A | P27815 | 14/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355422 | 0.84 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7361039 | 0.81 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7976207 | 0.77 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL2906067 | 0.74 | PDE5A (0.49) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL71976 | 0.74 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7353304 | 0.72 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6865665 | 0.70 | PDE4A (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL71378 | 0.70 | PDE4A (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7354886 | 0.69 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2905188 | 0.68 | PDE5A (0.50) | PDE4DPDE4APDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |