Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353299 | 0.85 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7355422 | 0.81 | PDE4D (0.47) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL7354873 | 0.81 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7355428 | 0.77 | PDE4D (0.47) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL20631457 | 0.76 | PDE5A (0.52) | PDE4DPDE4BPDE4APDE4CLMNA | |
| SCHEMBL22065381 | 0.76 | PDE5A (0.52) | PDE4DPDE4BPDE4APDE4CLMNA | |
| SCHEMBL2906067 | 0.75 | PDE5A (0.49) | PDE4DPDE4BPDE4APDE4CLMNA | |
| SCHEMBL71498 | 0.75 | PDE4D (0.64) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7360943 | 0.74 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL71286 | 0.71 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |