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SCHEMBL735543

SCHEMBL735543

CONc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 4/20 0.64
▸ HIF1A Q16665 1/20 0.46
▸ PRMT5 O14744 2/20 0.45
▸ WDR77 Q9BQA1 2/20 0.45
▸ SLC29A1 Q99808 1/20 0.45
▸ ADORA3 P0DMS8 1/20 0.44
▸ ADORA1 P30542 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22367653 0.89 TYMP (0.65) TYMPHIF1ASLC29A1ADORA3
SCHEMBL532674 0.86 TYMP (0.58) TYMPHIF1ASLC29A1ADORA3ADORA1
SCHEMBL6905301 0.86 TYMP (0.58) TYMPHIF1ASLC29A1ADORA3ADORA1
SCHEMBL2239678 0.86 TYMP (0.58) TYMPHIF1ASLC29A1ADORA3ADORA1
SCHEMBL4826069 0.86 TYMP (0.58) TYMPHIF1ASLC29A1ADORA3ADORA1
SCHEMBL733367 0.86 TYMP (0.47) TYMPPRMT5WDR77ADORA1
SCHEMBL29720432 0.86 TYMP (0.63) TYMPSLC29A1ADORA3
SCHEMBL11040442 0.86 TYMP (0.63) TYMPSLC29A1ADORA3
SCHEMBL18486296 0.85 TYMP (0.56) TYMPSLC29A1ADORA3
SCHEMBL7065752 0.85 TYMP (0.71) TYMPHIF1AADORA3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8138330-B2 Solid phase synthesis via deblocking immobilized nucleoside, then coupling acyl protected nucleoside phosphoramidite SIGMA-ALDRICH CO. LLC (US) 2012-03-20 — — US disclosed