Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PAM | P19021 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 4/20 | 0.46 |
| ▸ | CES1 | P23141 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5705163 | 0.98 | DGKA (0.55) | DGKALMNAPAMCES2CES1 | |
| SCHEMBL8587852 | 0.98 | DGKA (0.55) | DGKALMNAPAMCES2CES1 | |
| SCHEMBL9947473 | 0.98 | DGKA (0.55) | DGKALMNAPAMCES2CES1 | |
| SCHEMBL5698805 | 0.98 | DGKA (0.55) | DGKALMNAPAMCES2CES1 | |
| SCHEMBL7359360 | 0.93 | — | — | |
| SCHEMBL1712975 | 0.89 | TSHR (0.38) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL1712782 | 0.86 | MAPT (0.39) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL2261658 | 0.86 | MAPT (0.39) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL88274 | 0.79 | CYP1A2 (0.53) | DGKATSHRALDH1A1TDP1ALOX15 | |
| SCHEMBL5157552 | 0.78 | HSD17B10 (0.54) | LMNAMAPTTSHRPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | claimed |