Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10882905 | 0.84 | GAA (0.55) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL30834894 | 0.83 | KMT2A (0.54) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL27183316 | 0.82 | GAA (0.56) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL3381391 | 0.80 | ALDH1A1 (0.67) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL30354936 | 0.80 | ALDH1A1 (0.67) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL930847 | 0.79 | GAA (0.65) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL25383206 | 0.78 | ALDH1A1 (0.61) | CYP1A2GAARAB9AKMT2AMEN1 | |
| SCHEMBL30354821 | 0.78 | ALDH1A1 (0.61) | CYP1A2GAARAB9AKMT2AMEN1 | |
| SCHEMBL20796131 | 0.78 | MEN1 (0.74) | CYP1A2GAARAB9ANPC1KMT2A | |
| SCHEMBL29151235 | 0.78 | NPC1 (0.67) | GAARAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | disclosed |