Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 7/20 | 0.51 |
| ▸ | ACE | P12821 | 5/20 | 0.50 |
| ▸ | CPA1 | P15085 | 3/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16195620 | 0.82 | MME (0.58) | MMEACECPA1ACE2L3MBTL1 | |
| SCHEMBL7278010 | 0.80 | MME (0.56) | MMEACECPA1ACE2L3MBTL1 | |
| SCHEMBL7275396 | 0.80 | MME (0.56) | MMEACECPA1ACE2L3MBTL1 | |
| SCHEMBL22457555 | 0.77 | MME (0.53) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL38479 | 0.77 | MME (0.57) | MMEL3MBTL1NPSR1NAALAD2MMP2 | |
| SCHEMBL7937827 | 0.77 | MME (0.57) | MMEL3MBTL1NPSR1NAALAD2MMP2 | |
| SCHEMBL161255 | 0.77 | MME (0.57) | MMEL3MBTL1NPSR1NAALAD2MMP2 | |
| SCHEMBL38480 | 0.77 | MME (0.57) | MMEL3MBTL1NPSR1NAALAD2MMP2 | |
| SCHEMBL7272209 | 0.77 | MME (0.57) | MMEACECPA1ACE2L3MBTL1 | |
| SCHEMBL22457529 | 0.77 | MME (0.63) | MMEACECPA1ACE2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |