Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.57 |
| ▸ | ACE | P12821 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CPA1 | P15085 | 3/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356129 | 0.90 | MME (0.52) | MMEACELMNAL3MBTL1CPA1 | |
| SCHEMBL14398153 | 0.87 | MME (0.49) | MMEACELMNAL3MBTL1CPA1 | |
| SCHEMBL9554565 | 0.86 | PTPN1 (0.61) | MMEACEL3MBTL1CPA1ACE2 | |
| SCHEMBL7266724 | 0.84 | MEN1 (0.60) | ACEKMT2A | |
| SCHEMBL16195620 | 0.84 | MME (0.58) | MMEACELMNAL3MBTL1CPA1 | |
| SCHEMBL7275396 | 0.81 | MME (0.56) | MMEACELMNAL3MBTL1CPA1 | |
| SCHEMBL7278010 | 0.81 | MME (0.56) | MMEACELMNAL3MBTL1CPA1 | |
| SCHEMBL9554773 | 0.79 | PTPN1 (0.57) | MMEACEL3MBTL1CPA1ACE2 | |
| SCHEMBL8027170 | 0.79 | MME (0.88) | MMEACECPA1ACE2 | |
| SCHEMBL8032885 | 0.79 | MME (0.88) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750696-A | HYPOTENSIVE AGENTS | JAPAN TOBACCO INC. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0656356-A1 | DIOXACYCLOALKANE COMPOUND WITH RENIN-INHIBITING ACTIVITY | JAPAN TOBACCO INC. (JP) | 1995-06-07 | — | — | EP | disclosed |
| US-4963530-A | Renin inhibitor peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0283970-A2 | New peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-28 | — | — | EP | disclosed |