Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 10/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72986 | 0.88 | KMT2A (0.54) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL71189 | 0.86 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL7361220 | 0.80 | PDE4B (0.40) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL70409 | 0.79 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CSCN9A | |
| SCHEMBL70380 | 0.79 | PDE4D (0.72) | PDE4DPDE4BPDE4APDE4CSCN9A | |
| SCHEMBL70885 | 0.78 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CSCN9A | |
| SCHEMBL70834 | 0.78 | PDE4D (0.58) | PDE4DPDE4BPDE4APDE4CSCN9A | |
| SCHEMBL71331 | 0.76 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5024914 | 0.76 | KMT2A (0.63) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL6608115 | 0.75 | PDGFRB (0.45) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |