Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.71 |
| ▸ | METAP1 | P53582 | 6/20 | 0.71 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FNTA | P49354 | 1/20 | 0.49 |
| ▸ | FNTB | P49356 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7357848 | 0.99 | METAP2 (0.69) | METAP2METAP1NPY5RMAPTALDH1A1 | |
| SCHEMBL7358037 | 0.90 | METAP2 (0.70) | METAP2METAP1NPY5RALDH1A1HTT | |
| SCHEMBL7354371 | 0.89 | METAP2 (0.70) | METAP2METAP1EPHX1 | |
| Hydrochloric Acid SCHEMBL7353872 | 0.89 | METAP2 (0.69) | METAP2METAP1NPY5RALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7356659 | 0.88 | METAP2 (0.69) | METAP2METAP1EPHX1 | |
| SCHEMBL7351136 | 0.86 | METAP2 (0.66) | METAP2METAP1ALDH1A1EPHX1SMN1; SMN2 | |
| SCHEMBL7359630 | 0.84 | METAP2 (0.71) | METAP2METAP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7358960 | 0.84 | METAP2 (0.70) | METAP2METAP1SMN1; SMN2 | |
| SCHEMBL7307419 | 0.84 | METAP2 (0.72) | METAP2METAP1NPY5RCTSS | |
| SCHEMBL6487076 | 0.84 | METAP2 (0.72) | METAP2METAP1NPY5RCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |