Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.61 |
| ▸ | PDE4A | P27815 | 14/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030283 | 0.90 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL1031648 | 0.88 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858835 | 0.87 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7356316 | 0.84 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7355273 | 0.82 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6863990 | 0.79 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7363308 | 0.79 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL1028814 | 0.78 | PDE4B (0.71) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858838 | 0.78 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8558466 | 0.77 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |