Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.80 |
| ▸ | PDE4A | P27815 | 11/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030283 | 0.93 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858835 | 0.90 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL1026961 | 0.89 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7356320 | 0.88 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7356316 | 0.87 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858838 | 0.85 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6863990 | 0.84 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL1028814 | 0.83 | PDE4B (0.71) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7340773 | 0.82 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434462 | 0.82 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044023-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDYNYL ALKYLENE ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2011-01-19 | — | — | EP | disclosed |
| US-7671066-B2 | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-03-02 | — | — | US | disclosed |
| US-20080015226-A1 | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A.. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015226-A1 | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors | PDE4A, PDE4B, PDE12 | PDE4D 9/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.