Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PTPRG | P23470 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28003878 | 0.95 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1AALDH1A1LMNAMMP1 | |
| SCHEMBL31147036 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2HIF1AALDH1A1LMNAMMP1 | |
| SCHEMBL7008212 | 0.88 | MMP1 (0.47) | SMN1; SMN2HIF1AALDH1A1LMNAMMP1 | |
| SCHEMBL8376369 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2HIF1AALDH1A1LMNAMMP1 | |
| SCHEMBL27869079 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1AALDH1A1LMNAARG1 | |
| SCHEMBL9143721 | 0.84 | PTPN1 (0.51) | ALDH1A1LMNAPTPRCPTPN2PTPN1 | |
| SCHEMBL338742 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2HIF1AALDH1A1LMNAARG1 | |
| SCHEMBL7356368 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2HIF1AALDH1A1LMNAMMP1 | |
| SCHEMBL11172488 | 0.82 | PTPRB (0.58) | ALDH1A1PTPRCPTPN2PTPN1PTPRB | |
| SCHEMBL1487540 | 0.81 | BLM (0.51) | SMN1; SMN2HIF1AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722321-A4 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0722321-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009620-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |