Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR3A | P46098 | 3/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.54 |
| ▸ | HTR3B | O95264 | 2/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782033 | 0.81 | HTR4 (0.73) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL506271 | 0.81 | HTR4 (0.57) | HTR4HTR3ACHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL7367857 | 0.80 | HTR4 (0.72) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL16503998 | 0.79 | HTR4 (0.72) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7359161 | 0.78 | HTR2C (0.72) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL4303903 | 0.77 | HTR2C (0.65) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7360030 | 0.77 | HTR4 (0.69) | HTR4ACHECYP2D6CYP2C9SIGMAR1 | |
| Sulamserod SCHEMBL1082638 | 0.75 | CYP3A4 (0.66) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Sulamserod SCHEMBL29385909 | 0.75 | CYP3A4 (0.66) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7364991 | 0.74 | HTR4 (0.43) | HTR4HTR2CHTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700383-B1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX INC (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5763458-A | NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS | SYNTEX (U.S.A.) INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0700383-A1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027965-A1 | NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1994-12-08 | — | — | WO | disclosed |