Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.54 |
| ▸ | PDE4A | P27815 | 8/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361019 | 0.92 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7356069 | 0.88 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7353627 | 0.86 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7351599 | 0.86 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7357327 | 0.85 | PDE4D (0.56) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7356090 | 0.84 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7355273 | 0.84 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7363191 | 0.81 | PDE4B (0.56) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7361933 | 0.79 | PDE4D (0.76) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7352396 | 0.78 | TAS1R3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |