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Sugi Predict / Compounds / SCHEMBL7357635

SCHEMBL7357635

SCHEMBL7357635

CC(C)[C@H](NC(=O)N1CCC(NCC(=O)OC(C)(C)C)CC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(F)(F)F

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CMA1 P23946 18/20 0.66
▸ ELANE P08246 2/20 0.60
▸ CTSG P08311 1/20 0.60
▸ CTRC Q99895 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7349272 1.00 CMA1 (0.66) CMA1ELANECTSGCTRC
SCHEMBL7349280 1.00 CMA1 (0.66) CMA1ELANECTSGCTRC
Hydrochloric Acid SCHEMBL6699938 0.87 ELANE (0.66) CMA1ELANECTSGCTRC
Hydrochloric Acid SCHEMBL7357221 0.87 ELANE (0.66) CMA1ELANECTSGCTRC
Hydrochloric Acid SCHEMBL6699949 0.87 ELANE (0.66) CMA1ELANECTSGCTRC
SCHEMBL7349967 0.83 CMA1 (0.52) CMA1ELANE
SCHEMBL7356809 0.82 ACE (0.57) CMA1
SCHEMBL7357630 0.81 CMA1 (0.45) CMA1ELANECTSGCTRC
SCHEMBL7349275 0.81 CMA1 (0.45) CMA1ELANECTSGCTRC
SCHEMBL7354959 0.81 CMA1 (0.45) CMA1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993025574-A1 INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE PFIZER INC. (US) 1993-12-23 — — WO disclosed