Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008902 | 0.86 | HRH1 (0.47) | HRH1HRH4HRH2HRH3MAPT | |
| SCHEMBL7350260 | 0.84 | HRH1 (0.55) | HRH1HRH4HRH2HRH3SMN1; SMN2 | |
| SCHEMBL7353364 | 0.83 | DRD4 (0.44) | HRH1HRH4HRH2HRH3DRD4 | |
| SCHEMBL7349951 | 0.78 | HRH4 (0.56) | HRH1HRH4HRH2HRH3SMN1; SMN2 | |
| SCHEMBL7350762 | 0.74 | HRH4 (0.52) | HRH1HRH4HRH2HRH3SMN1; SMN2 | |
| SCHEMBL8009147 | 0.72 | DRD4 (0.58) | TSHRMAPK1DRD4ALDH1A1LMNA | |
| SCHEMBL6811660 | 0.68 | SLC18A3 (0.52) | HRH1DRD4MEN1KMT2A | |
| SCHEMBL1389036 | 0.65 | CYP1A2 (0.56) | HRH1HRH4HRH3TSHRDRD4 | |
| SCHEMBL13200326 | 0.65 | DYRK1A (0.50) | HRH1HRH4HRH2HRH3SMN1; SMN2 | |
| SCHEMBL7356862 | 0.65 | BCHE (0.46) | SMN1; SMN2TSHRNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880121-A | SEROTONIN 5HT3 ANTAGONIST, USEFUL FOR TREATING ANXIETY, PHYCHIATRIC DISORDERS, NAUSEA, VOMITING AND DRUG DEPENDENCY | HOECHST MARION ROUSSEL INC. (US) | 1999-03-09 | — | — | US | claimed |
| EP-0874833-A1 | 4,5-DIHYDRONAPHTH 1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-04 | — | — | EP | claimed |
| WO-1997025317-A1 | 4,5-DIHYDRONAPHTH[1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-17 | — | — | WO | claimed |
| US-5880121-A | SEROTONIN 5HT3 ANTAGONIST, USEFUL FOR TREATING ANXIETY, PHYCHIATRIC DISORDERS, NAUSEA, VOMITING AND DRUG DEPENDENCY | HOECHST MARION ROUSSEL INC. (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0874833-A1 | 4,5-DIHYDRONAPHTH 1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997025317-A1 | 4,5-DIHYDRONAPHTH[1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-17 | — | — | WO | disclosed |