SCHEMBL7350762

SCHEMBL7350762

c1ccc2c(c1)CCc1c-2noc1N1CCCNCC1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 4/20 0.52
KDM4E B2RXH2 1/20 0.38
HTR7 P34969 5/20 0.38
NCF1 P14598 1/20 0.38
CHRNB2 P17787 2/20 0.37
CHRNA4 P43681 2/20 0.37
HRH2 P25021 1/20 0.37
HRH1 P35367 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
HTR2B P41595 2/20 0.37
HTR3A P46098 2/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
TSHR P16473 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HTR1A P08908 1/20 0.36
HTR6 P50406 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7349951 0.95 HRH4 (0.56) HRH4KDM4EHTR7HRH2HRH1
SCHEMBL7355029 0.81 CYP1A2 (0.48) KDM4EHTR7NCF1CHRNB2CHRNA4
SCHEMBL7350260 0.80 HRH1 (0.55) HRH4KDM4EHRH2HRH1HRH3
SCHEMBL7358955 0.75 CYP1A2 (0.49) KDM4ENCF1HTR2BHTR3AALDH1A1
SCHEMBL7357907 0.74 HRH1 (0.41) HRH4KDM4EHRH2HRH1HRH3
SCHEMBL7353364 0.74 DRD4 (0.44) HRH4HRH2HRH1HRH3HTR2B
SCHEMBL8008902 0.72 HRH1 (0.47) HRH4HRH2HRH1HRH3HTR2B
SCHEMBL604895 0.69 HRH4 (0.93) HRH4HRH2HRH1HRH3HTR2B
SCHEMBL8017371 0.69 SMN1; SMN2 (0.35) HRH4KDM4EHRH2HRH1HRH3
SCHEMBL605567 0.68 HRH4 (1.00) HRH4KDM4EHRH2HRH1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5880121-A SEROTONIN 5HT3 ANTAGONIST, USEFUL FOR TREATING ANXIETY, PHYCHIATRIC DISORDERS, NAUSEA, VOMITING AND DRUG DEPENDENCY HOECHST MARION ROUSSEL INC. (US) 1999-03-09 US claimed
US-5880121-A SEROTONIN 5HT3 ANTAGONIST, USEFUL FOR TREATING ANXIETY, PHYCHIATRIC DISORDERS, NAUSEA, VOMITING AND DRUG DEPENDENCY HOECHST MARION ROUSSEL INC. (US) 1999-03-09 US disclosed
EP-0874833-A1 4,5-DIHYDRONAPHTH 1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY HOECHST MARION ROUSSEL, INC. (US) 1998-11-04 EP disclosed
WO-1997025317-A1 4,5-DIHYDRONAPHTH[1,2-C]ISOXAZOLES AND DERIVATIVES THEREOF HAVING CNS ACTIVITY HOECHST MARION ROUSSEL, INC. (US) 1997-07-17 WO disclosed