Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | SCN4A | P35499 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8703025 | 1.00 | TSHR (0.54) | TSHRLOXL2DPP4MEN1MAPT | |
| SCHEMBL1922926 | 0.82 | TSHR (0.56) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL6351539 | 0.80 | TSHR (0.54) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL6739582 | 0.80 | TSHR (0.54) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL6740953 | 0.80 | TSHR (0.54) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL394915 | 0.78 | CYP1A2 (0.43) | TSHRLOXL2DPP4TDP1CYP1A2 | |
| SCHEMBL29239979 | 0.78 | PNMT (0.39) | TSHRLOXL2DPP4MAPTCYP1A2 | |
| SCHEMBL28190550 | 0.78 | CYP3A4 (0.44) | TSHRLOXL2DPP4MEN1MAPT | |
| SCHEMBL12490636 | 0.77 | TSHR (0.50) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL28234295 | 0.77 | TSHR (0.50) | TSHRMEN1MAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036061-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029664-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-06-17 | — | — | WO | disclosed |
| US-5736568-A | ANTIALLERGENS; IMMUNOMODULANTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-04-07 | — | — | US | disclosed |