Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321450 | 0.84 | KDM4E (0.53) | KDM4EERBB2FLT1EPHA2KDR | |
| SCHEMBL7325971 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1SIGMAR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5881222 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1SIGMAR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5082574 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1SIGMAR1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL7331859 | 0.78 | KDM4E (0.56) | KDM4EERBB2FLT1EPHA2KDR | |
| SCHEMBL7327714 | 0.74 | HCRTR1 (0.55) | KDM4ETHRBALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL12885024 | 0.74 | KDM4E (0.69) | KDM4ETHRBALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6996144 | 0.73 | KDM4E (0.52) | KDM4ETHRBALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL6996149 | 0.73 | KDM4E (0.52) | KDM4ETHRBALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL20503253 | 0.72 | KDM4E (0.63) | KDM4ETHRBALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | claimed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | claimed |