Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5881222 | 0.99 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2SIGMAR1HRH1 | |
| Hydrochloric Acid SCHEMBL5082574 | 0.98 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2SIGMAR1HRH1 | |
| Hydrochloric Acid SCHEMBL7453458 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2HRH3POLB | |
| SCHEMBL7321964 | 0.86 | HRH3 (0.64) | SIGMAR1HRH3 | |
| SCHEMBL7326091 | 0.86 | HRH3 (0.67) | SMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL27431543 | 0.85 | SIGMAR1 (0.64) | SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL9528342 | 0.85 | HRH3 (0.65) | SMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL7326809 | 0.84 | SIGMAR1 (0.49) | SIGMAR1HRH3 | |
| SCHEMBL7323336 | 0.84 | HRH3 (0.44) | SIGMAR1HRH3SLC6A4 | |
| SCHEMBL9370762 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2SIGMAR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542846-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-05-26 | — | — | EP | claimed |
| WO-1992002502-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | claimed |
| EP-0799201-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 4-ETHYL-PIPERIDINES | NEUROSEARCH AS (DK) | 2001-09-26 | — | — | EP | disclosed |
| EP-0799201-A1 | A PROCESS FOR THE PREPARATION OF SUBSTITUTED 4-ETHYL-PIPERIDINES AND AN INTERMEDIATE FOR THE PREPARATION OF SAME | NEUROSEARCH A/S (DK) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019452-A1 | A PROCESS FOR THE PREPARATION OF SUBSTITUTED 4-ETHYL-PIPERIDINES AND AN INTERMEDIATE FOR THE PREPARATION OF SAME | NEUROSEARCH A/S (DK) | 1996-06-27 | — | — | WO | disclosed |