Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 11/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 11/20 | 1.00 |
| ▸ | GABRA5 | P31644 | 11/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 10/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 10/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 9/20 | 1.00 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349566 | 0.80 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7356856 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7354404 | 0.79 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7349707 | 0.79 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7349994 | 0.77 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7349676 | 0.76 | GABRG2 (0.70) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7361535 | 0.74 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7352428 | 0.74 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7353193 | 0.73 | GABRG2 (0.70) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7356745 | 0.72 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |