Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19857564 | 0.81 | PARP1 (0.46) | PARP1KDM4EL3MBTL1PKN1PKN2 | |
| SCHEMBL16497015 | 0.74 | PARP1 (0.49) | PARP1KDM4EL3MBTL1PARP2PARP3 | |
| SCHEMBL7363550 | 0.74 | EGLN1 (0.35) | PARP1KDM4EL3MBTL1PKN1PKN2 | |
| SCHEMBL3643581 | 0.73 | EGLN3 (0.43) | KDM4E | |
| SCHEMBL27249587 | 0.73 | PARP1 (0.47) | PARP1KDM4EL3MBTL1PKN1PKN2 | |
| SCHEMBL1290332 | 0.70 | PARP1 (0.47) | PARP1KDM4EL3MBTL1 | |
| SCHEMBL29829541 | 0.68 | EGLN1 (0.49) | PARP1PARP2PARP3EGLN1 | |
| SCHEMBL27549590 | 0.68 | POLB (0.53) | PARP1KDM4EL3MBTL1PARP2PARP3 | |
| SCHEMBL29829801 | 0.68 | PARP1 (0.54) | PARP1PARP2PARP3EGLN1 | |
| SCHEMBL8648021 | 0.67 | LMNA (0.50) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107966-A2 | OXO-PYRIDOIMIDAZOLE-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000010973-A2 | OXO-PYRIDOIMIDAZOLE-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-03-02 | — | — | WO | disclosed |