Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.60 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281729 | 0.91 | REN (0.56) | RENCTSSCTSK | |
| SCHEMBL27673686 | 0.89 | REN (0.61) | RENCTSSCTSK | |
| SCHEMBL10669316 | 0.89 | REN (0.61) | RENCTSSCTSK | |
| SCHEMBL10675193 | 0.89 | REN (0.61) | RENCTSSCTSK | |
| SCHEMBL7359298 | 0.89 | REN (0.61) | RENCTSSCTSK | |
| SCHEMBL9876551 | 0.88 | REN (0.56) | RENCTSSCTSK | |
| SCHEMBL10587538 | 0.85 | REN (0.54) | RENCTSSCTSK | |
| SCHEMBL7326076 | 0.85 | REN (0.51) | RENCTSSCTSK | |
| SCHEMBL7266599 | 0.84 | REN (0.58) | RENCTSSCTSK | |
| SCHEMBL7272241 | 0.84 | REN (0.58) | RENCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |