Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.67 |
| ▸ | PLG | P00747 | 6/20 | 0.63 |
| ▸ | PLAT | P00750 | 6/20 | 0.63 |
| ▸ | KLK1 | P06870 | 6/20 | 0.63 |
| ▸ | F2 | P00734 | 5/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358951 | 1.00 | PLAU (0.67) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7339552 | 0.90 | PLAU (0.81) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7341506 | 0.90 | PLAU (0.81) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7345139 | 0.80 | PLAU (1.00) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7352771 | 0.79 | PLAU (0.70) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL6436054 | 0.78 | PLAU (1.00) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7343365 | 0.77 | PLAU (0.73) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7343375 | 0.77 | PLAU (0.73) | PLAUPLGPLATKLK1F2 | |
| SCHEMBL7352789 | 0.74 | PLAU (0.50) | PLAUPLGPLATKLK1F2 | |
| Trifluoroacetic Acid SCHEMBL7352867 | 0.74 | PLAU (0.90) | PLAUPLGPLATKLK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |